Ai-Ling Lin

Ai-Ling Lin

Company: University of Kentucky

Job title: Associate Professor


Dr. Ai-Ling Lin is currently a tenured Associate Professor in the Sanders-Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, Department of Neuroscience and Department of Biomedical Engineering of the University of Kentucky. Originally from Taiwan, Dr. Lin completed her PhD and Postdoctoral training as a medical physicist from the University of Texas Health Science Center in San Antonio, TX. She has developed and applied multi-metric neuroimaging methods (MRI, MRS and PET) to determine brain vascular and metabolic functions, which allow her to identify effects of caloric restriction, ketogenic diet, prebiotic diet, and Rapamycin on cognitive aging and Alzheimer’s disease (AD) with various animal models. She has recently extended her research to include gut microbiome and metabolomics analyses for identifying gut-brain interactions in the context of brain aging and AD. It is her goal to identify effective individualized interventions to preserve brain functions in aging and prevent AD via gut-brain axis.

Dr. Lin has been awarded $2.88 million from the National Institute on Aging to study Rapamycin’s potential to prevent Alzheimer’s disease, and another $3.61 million to study effects of prebiotic diet to reduce Alzheimer’s disease risk via gut-brain axis in an APOE4 mouse model.

Dr. Lin has numerous peer-reviewed articles, book chapters and poster awards to her credit, and directs or co-directs grants from the National Institute on Aging (NIA) and Office of Dietary Supplement (ODS) of the National Institutes of Health (NIH), the American Federation for Aging Research (AFAR), and the Donors Cure Foundation.


Dietary Inulin Alters the Gut Microbiome, Enhances Systemic Metabolism & Reduces Neuroinflammation in an APOE4 Mouse Model 2:30 pm

• Carriers of the apolipoprotein ε4 allele (APOE4) develop systemic metabolic dysfunction decades before showing Alzheimer’s disease (AD) symptoms; preserving metabolic function early on may be critical to reducing the risk for AD • Here we show that prebiotic inulin increases beneficial gut microbiota, elevates short chain fatty acids, tryptophan-derived metabolites and bile acids, and…Read more

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