Dietary Inulin Alters the Gut Microbiome, Enhances Systemic Metabolism & Reduces Neuroinflammation in an APOE4 Mouse Model

Time: 2:30 pm
day: Day One


• Carriers of the apolipoprotein ε4 allele (APOE4) develop systemic metabolic dysfunction decades before showing Alzheimer’s disease (AD) symptoms; preserving metabolic function early on may be critical to reducing the risk for AD
• Here we show that prebiotic inulin increases beneficial gut microbiota, elevates short chain fatty acids, tryptophan-derived metabolites and bile acids, and reduces inflammatory gene expression in the brain in young, asymptomatic
APOE4 transgenic mice
• Using a prebiotic diet to enhance systemic metabolism may be useful for reducing AD risk in asymptomatic APOE4 carriers